Beilstein J. Org. Chem.2017,13, 1079–1084, doi:10.3762/bjoc.13.107
self-intermolecularoxidativecoupling of aryl ketones using I2−tert-butyl hydroperoxide (TBHP). Under the optimum conditions, various aryl ketones gave the corresponding products in moderate to excellent yields. A series of control experiments were performed; the results suggest the involvement of
H2O in the TBHP solvent.
Keywords: aryl ketones; iodine; self-intermolecularoxidativecoupling; self-sequential assembly; TBHP; Introduction
In recent years, α-acetoxyaryl ketones have attracted considerable interest because this structural motif is found in a variety of biologically active natural
been made [12], examples of the synthesis of α-acetoxyaryl ketones through self-intermolecularoxidativecoupling of aryl ketones are still rare. Yan and coworkers reported the preparation of α-acyloxyaryl ketones from aryl ketones using a Pybox-copper(II) catalyst [13]. However, the substrate scope